{"id":1502,"date":"2013-11-22T11:47:00","date_gmt":"2013-11-22T17:47:00","guid":{"rendered":"https:\/\/www.rqmplus.com\/?p=1502"},"modified":"2025-09-03T09:52:29","modified_gmt":"2025-09-03T14:52:29","slug":"molecular-weight-analysis-how-to","status":"publish","type":"post","link":"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/","title":{"rendered":"Molecular Weight Analysis: How to Measure MW?"},"content":{"rendered":"\n<p>Analyzing the molecular weight of both natural and synthetic polymers is extremely complex, and almost impossible to carry out with exactness. Unlike elemental analysis \u2013 which focuses on the chemical composition of samples under test \u2013 molecular weight analysis considers the number of small molecules present in a polymeric chain. This number can vary significantly, even within specific polymer groups.<\/p>\n\n\n\n<p>Yet accurate molecular weight analysis is an important part of quality assurance and control (QA\/QC), providing the means for process engineers to assess various product performance parameters. The molecular weight \u2013 or MW \u2013 of plastics is a good indicator of important mechanical properties such as durability, strength, and toughness. In bioactive polymers, such as those found in drug delivery systems, MW can determine the release rate of pharmaceutical compounds in vitro.<\/p>\n\n\n\n<p>So, it is often vital to perform robust molecular weight analysis to get the greatest results from polymeric goods and systems. At RQM+ Lab Services, we are experts in molecular weight determination, with an excellent grasp of the underlying theory of MW measurements and the necessary tools to complete any analytical run. This is how we perform molecular weight analysis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Molecular Weight Analysis: The Basics<\/h2>\n\n\n\n<p>First, we should revisit the idea that molecular weight is not a definitive number but is instead based on a series of values that form a bell curve distribution that indicates an average MW value. Calculating this distribution is carried out by multiplying the mass of each repeating monomer in the polymeric chain then adding the mass of either end group. In the resulting bell curve, the lowest portion of the curve is the number average MW (M<sub>n<\/sub>) while the highest portion is known as the Z average (M<sub>z<\/sub>). That which is closest to the middle of the curve is the weight average (M<sub>w<\/sub>).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Molecular Weight Analysis, the RQM+ Way<\/h2>\n\n\n\n<p>At RQM+ Lab Services, we rely on our demonstrable expertise in gel permeation chromatography (GPC) to measure the molecular weights of&nbsp;various polymers with absolute precision. This is the industry-standard technique used to separate compounds into their composite parts by various molecular properties, including weight. Using a host of accurate detection technologies (multi-angle light scattering, refractive index, viscometry, etc.) we can determine the entire MW distribution of samples separated via a choice of GPC columns.<\/p>\n\n\n\n<p>Our background in GPC column design and engineering makes RQM+ Lab Services&nbsp;the go-to provider of GPC-related services and studies.<\/p>\n\n\n\n<p>Or, for any questions regarding molecular weight analysis for specific polymer grades and types, simply <a href=\"\/about\/contact\">contact a member<\/a>&nbsp;of the RQM+ Lab Services team today.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Analyzing the molecular weight of both natural and synthetic polymers is extremely complex, and almost impossible to carry out with&#8230;<\/p>\n","protected":false},"author":13,"featured_media":976,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"resource-type":[28],"topic":[],"region":[],"class_list":["post-1502","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","resource-type-blog"],"acf":[],"card_info":{"title":"Molecular Weight Analysis: How to Measure MW?","link":"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/","link_target":"_self","name":"Blog","slug":"blog","thumbnail":"https:\/\/www.rqmplus.com\/wp-content\/uploads\/2025\/03\/women-looking-at-paper.jpg","excerpt":"Analyzing the molecular weight of both natural and synthetic polymers is extremely complex, and almost impossible to carry out with...","display_date":"November 22, 2013"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Molecular Weight Analysis: How to Measure MW? | RQM+<\/title>\n<meta name=\"description\" content=\"RQM+ Lab Services is an expert in molecular weight analysis. In this article, we aim to explore how to measure the MW of polymers in depth.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular Weight Analysis: How to Measure MW? | RQM+\" \/>\n<meta property=\"og:description\" content=\"RQM+ Lab Services is an expert in molecular weight analysis. In this article, we aim to explore how to measure the MW of polymers in depth.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/\" \/>\n<meta property=\"og:site_name\" content=\"RQM+\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/RQMplus\" \/>\n<meta property=\"article:published_time\" content=\"2013-11-22T17:47:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-03T14:52:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.rqmplus.com\/wp-content\/uploads\/2025\/03\/women-looking-at-paper.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1800\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Alex Smith\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@RQMplus\" \/>\n<meta name=\"twitter:site\" content=\"@RQMplus\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Alex Smith\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/\"},\"author\":{\"name\":\"Alex Smith\",\"@id\":\"https:\/\/www.rqmplus.com\/#\/schema\/person\/3a014f17a9e33ae269967ec748fea72e\"},\"headline\":\"Molecular Weight Analysis: How to Measure MW?\",\"datePublished\":\"2013-11-22T17:47:00+00:00\",\"dateModified\":\"2025-09-03T14:52:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/\"},\"wordCount\":434,\"publisher\":{\"@id\":\"https:\/\/www.rqmplus.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.rqmplus.com\/wp-content\/uploads\/2025\/03\/women-looking-at-paper.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/\",\"url\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/\",\"name\":\"Molecular Weight Analysis: How to Measure MW? | RQM+\",\"isPartOf\":{\"@id\":\"https:\/\/www.rqmplus.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.rqmplus.com\/blog\/molecular-weight-analysis-how-to\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.rqmplus.com\/wp-content\/uploads\/2025\/03\/women-looking-at-paper.jpg\",\"datePublished\":\"2013-11-22T17:47:00+00:00\",\"dateModified\":\"2025-09-03T14:52:29+00:00\",\"description\":\"RQM+ Lab Services is an expert in molecular weight analysis. 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